Real Resilience

Neuronugget #3

Which stress-responsive molecules impact resilience in humans:

1. Neuropeptides:

   • Neuropeptides, such as oxytocin and vasopressin, play a role in social bonding, stress regulation, and emotional resilience.

   • Oxytocin, often called the “cuddle hormone,” promotes prosocial behavior and buffers stress responses. It enhances social support and fosters resilience.

   • Vasopressin influences water balance, but it also affects stress coping. Variations in the vasopressin receptor gene are associated with individual differences in resilience.

2. Brain-Derived Neurotrophic Factor (BDNF):

   • BDNF supports neuronal survival, growth, and synaptic plasticity.

   • Stress reduces BDNF levels, impacting resilience. However, physical exercise, mindfulness, and social support can increase BDNF expression, enhancing resilience.

3. Glucocorticoid Receptors (GRs):

   • GRs mediate the effects of cortisol (a stress hormone).

   • Resilient individuals have efficient GR functioning, allowing better stress regulation and recovery.

4. Epigenetic Modifications:

   • DNA methylation and histone modifications influence gene expression.

   • Epigenetic changes due to stress can impact resilience. For example, altered glucocorticoid receptor expression affects stress responses.

In summary, these molecules interact with neural circuits, hormonal systems, and genetic pathways, shaping our ability to bounce back from adversity.

We must be willing to let go of the life we planned so as to have the life that is waiting for us.